1996-2023 RxList, Inc. An Internet Brands company. View abstract. Reductions in calcium, albumin, albumin/globulin ratio, hematocrit, and white blood cell and platelet counts occurred in some rats.Rasekh 2008, In humans, toxicity has been observed with other guanidine derivatives. It is believed to have been used as a diuretic and tonic for typhoid conditions and as a nervous system stimulant.Chevallier 1996, Grieve 1931 Goat's rue has been used as a soak for tired feet and as an herb in cheese making.Grieve 1931 Hill's Universal Herbal (1832) mentions the addition of the dried flowers to boiling water to make an infusion for drinking to induce sweating and reduce fever.Grieve 1931 The plant is widely cultivated as cattle feed.Chevallier 1996 Reports of lactogenic effects of the plant exist.Heiss 1968 The name "Galega" is derived from "gala" meaning "milk," and "agein" meaning "production. 1986;28(4):309-315. In combination with other herbs, goat's rue is used to stimulate the adrenal gland and pancreas; to protect the liver; for digestion problems; and to start the flow of breast milk. Diabetes Care 2004;27(7):1791-1793. The parts that grow above the ground are used to make medicine. It is available in the market or you can even prepare it at home. Distribution and habitat Petricic, J. and Kalodera, Z. Galegin in the goat's rue herb: toxicity, antidiabetic activity and content determination. SCHREIBER, K., AURICH, O., and PUFAHL, K. [Isolation of peganine from goat's-rue, Galega officinalis L.]. J Environ.Pathol.Toxicol.Oncol. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Dt. Phenolic compounds protect the healthy cells of the body against damage and destruction and maintain DNA integrity. Novel weight-reducing activity of Galega officinalis in mice. [8] The Latin specific epithet officinalis refers to plants with some medicinal, culinary or herbal attributes. February 21, 2022 Goat's rue (Galega officinalis) is a herbaceous plant that belongs to the Fabaceae (Pea) family. HerbalGram 2008;76:44-49. But it is unclear if goat's rue has this effect when taken by people. (Atanasov 1999, Atanasov 2000, Atanasov 2002, Atanasov 2016) It may also possess antioxidant effects, which can vary according to the type of extract. Be careful not to confuse goat's rue (Galega officinalis) with rue (Ruta graveolens). Goat's rue supplements are available in the form of capsules and herbal tea. Additionally, skin diseases caused by bacteria can also be treated with goats rue. Benefits/Uses Goat's rue can help many breastfeeding women build more breast tissue and produce more breast milk. LAPYNINA, L. A. Significantly higher milk production was noted with treatment at 7 days and 30 days compared with placebo (P<0.05). 1981;23(6):410-412. 2005 - 2023 WebMD LLC, an Internet Brands company. View abstract. Goat's rue might slow blood clotting. (Chevallier 1996)Animal and in vitro dataGoat's rue increases milk secretion from 35% to 50% in cows. 1996-2023 WebMD, LLC. View abstract. Schafer, J. and Stein, M. [On the variability of substances contained in the goat's rue (Galega officinalis L.)]. Pharmaceutical and Pharmacological Letters 1996;6:86-89. Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Be careful not to confuse goat's rue (Galega officinalis) with rue (Ruta graveolens). View abstract. Misbin, R. I. Information from this source is evidence-based and objective, and without commercial influence. Neef H, Augustijns P, Declercq P, et al. Reuter, G. [ARGININE AS THE FIRST STAGE OF GALEGINE IN GALEGA OFFICINALIS L. ON THE BIOCHEMISTRY AND PHYSIOLOGY OF GALEGINE IN GALEGA OFFICINALIS L. Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. Pundarikakshudu, K., Patel, J. K., Bodar, M. S., and Deans, S. G. Anti-bacterial activity of Galega officinalis L. (Goat's Rue). December 7, 2022 416 19 351 What Is Goat Milk? Selenium fights oxidative stress and prevents absorption of pro-oxidants. View abstract. Increase Your Breast Milk Supply Naturally Benefits and Uses Cancer research studies are now being carried out to see if goat's rue is useful in the fight against cancer. Vuksan, V. and Sievenpiper, J. L. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Goat's rue and its derivatives have been used in the management of diabetes mellitus to reduce blood sugar levels. Goat's rue (Galega officinalis) leaves and flowering tops contain numerous guanidine derivatives, including galegine which may cause hypoglycemia. 2005;15(3):149-160. (Karakas 2016, Khodadadi 2016) G. officinalis extracts were also noted to have variable cytotoxic activity against glioblastoma and lung adenocarcinoma cell lines. This information should not be used to decide whether or not to take this product. Health benefits of Goat's Rue. Folia Med.(Plovdiv.) Avoid use. They reduce the load of free radicals, which otherwise worsen the condition. View abstract. Scientific Name(s): Galega officinalis L.Common Name(s): French lilac, Galega, Goat's rue, Italian fitch, Pestilenzkraut (German), Professor-weed. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells (Caco-2). Monitor your blood sugar closely. Goats rue has also been used for its lactogenic effects to increase milk production. Arch.Pharm (Weinheim) 1963;296:516-522. Effect of Galega officinalis L. extract on platelet aggregation in rats. Although treatment with G. officinalis was accompanied by a transient decrease in food intake in one study, pair-feeding indicated that the effects on body weight were at least partially independent of changes in food intake. View abstract. 1965;20:57-62. 2000;69(3):235-240. View abstract. Supports pancreas function. Medicinal plants. [ON FLAVONOID COMPOSITION OF GALEGA OFFICINALIS.]. These are some of the key Goat's Rue benefits: Protects the liver. Other uses for goat's rue herb are in the treatment of rheumatism, bladder problems, fever, hard coughs, irregular menstruation, and as a galactagogue. View abstract. Chemical Composition. View abstract. 1965;20:57-62. Rasekh, H. R., Nazari, P., Kamli-Nejad, M., and Hosseinzadeh, L. Acute and subchronic oral toxicity of Galega officinalis in rats. Barger, G. and White, F. D. Galuteolin, a New Glucoside from Galega Officinalis. View abstract. (Neef 1996) In one study, an extract of G. officinalis normalized leukocyte functionality and reduced apoptosis manifestations in streptozotocin-induced diabetes. Atanasov, A. T., Chorbanov, B. P., and Dimitrov, B. D. Anti-aggregation activity of crude water extract of Galega officinalis L. fractionated on Sephadex G-25 and Sepharose 4B. Aids digestion problems. Microscopic alterations in the lungs were also noted.Keeler 1986, Keeler 1988 In 3 sheep with poisoning from G. officinalis, an asphyxic syndrome occurred and led to death within hours.Puyt 1981 Galegine is suspected to be the cause of toxicity.Khodadadi 2016, In a murine model, G. officinalis at doses up to 5 g/kg was not associated with increased mortality or toxic symptoms. The phantom of lactic acidosis due to metformin in patients with diabetes. The plant has no scent unless bruised, in which case it emits a disagreeable odor, from which the name "goat's rue" may have originated. Cancer research studies are now forming to see if this supplement can be used to help fight various types of cancer. These compounds inhibit the growth and colonization of the bacteria in the body. Therapeutic Effects of Goat's Rue The rich content of guanidine in goat's rue has power of lowering blood glucose level and increases insulin sensitivity. Pundarikakshudu, K., Patel, J. K., Bodar, M. S., and Deans, S. G. Anti-bacterial activity of Galega officinalis L. (Goat's Rue). RxList does not provide medical advice, diagnosis or treatment. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others. Goats rue is a plant that has been empirically used from the 16th century onwards to heal diverse afflictions, such as poisonous animal bites, though only during the last decades have its actual properties been discovered. Bailey, C. J. and Day, C. Metformin: its botanical background. Vitamin D Deficiency: How Much Vitamin D Is Enough. This pretty herb with an unattractive name has fallen into disfavor in . Huxtable CR, Dorling RR, Colegate SM. Intake of goats rue along with a calorie-restricted diet helps in losing excess body fat. J.Med.Food 2002;5(4):229-234. It is believed to have been used as a diuretic and tonic for typhoid conditions and as a nervous system stimulant.Chevallier 1996, Grieve 1931 Goat's rue has been used as a soak for tired feet and as an herb in cheese making.Grieve 1931 Hill's Universal Herbal (1832) mentions the addition of the dried flowers to boiling water to make an infusion for drinking to induce sweating and reduce fever.Grieve 1931 The plant is widely cultivated as cattle feed.Chevallier 1996 Reports of lactogenic effects of the plant exist.Heiss 1968 The name "Galega" is derived from "gala" meaning "milk," and "agein" meaning "production. At this time there is not enough scientific information to determine an appropriate range of doses for goat's rue. (Palit 1998, Palit 1999) Modifications to galegine, including replacement of the dimethylallyl group by various benzyl substituents, enhanced weight loss ability. An in vitro study demonstrated that an extract of G. officinalis as well as galegine visually changed the color of melanoma cells and reduced the melanin content. Flavonoids are dominant substances in goats rue that hold anti-cancer activity. Goat's rue contains a chemical that may lower blood sugar in a test tube. At this time there is not enough scientific information to determine an appropriate range of doses for goat's rue. View abstract. Atanasov, A. T., Chorbanov, B. P., and Dimitrov, B. D. Anti-aggregation activity of crude water extract of Galega officinalis L. fractionated on Sephadex G-25 and Sepharose 4B. This information relates to an herbal, vitamin, mineral or other dietary supplement. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Be sure to follow relevant directions on product labels and consult your, The Role Gut Bacteria Plays on the Overall Body, Breast-feeding. Experientia 7-15-1961;17:302-303. 2005;35(3):258-260. Palit, P., Furman, B. L., and Gray, A. I. By using, reading or accessing any page on this website, you agree that you have read, understood and will abide by the Disclaimer, Privacy Policy and Terms of Use. 2005;15(3):149-160. Regular consumption of goats rue helps in improving the overall lipid profile. Pharmazie 1969;24(6):358. Goat's rue plant encompasses key chemical compounds including galegine, hydroxygalegine, guanidine, flavones, kaempferol and quercetin that are known to exhibit potent therapeutic actions. Taking goat's rue along with diabetes medications might cause your blood sugar to go too low. (Stosic 1993) Goat's rue may be of some value as supportive therapy or in early stages of adult-onset diabetes, with guidance from a physician, but use may not be justified based on severity of the disease, adverse effects/interactions, and the availability of better alternatives. Goat's Rue - Uses & Health Benefits. 1965;20:57-62. Lemus, I., Garcia, R., Delvillar, E., and Knop, G. Hypoglycaemic activity of four plants used in Chilean popular medicine. "Khodadadi 2016, Guanidine derivatives, including galegine (isoamylene-guanidine) and hydroxygalegine, are present in all parts of goat's rue.Bisset 1994, Chevallier 1996 Several older reports confirm the presence of galegine and related compounds.Barthel 1968, Desvages 1969, Leonard 1972, Reuter 1967, Reuter 1969, Schfer 1967 A later study discusses the presence of several guanidine derivatives, including galegine and 4-hydroxygalegine flavones, and flavone glycosides.Rosca 1988 The flavonol triglycosides kaempferol and quercetin have been found in the plant,Champavier 2000 as have norterpenoid and sesquiterpenoid glycosides, including the rare norterpenoid glycoside dearabinosyl pneumonanthoside.Champavier 1999 Vasicine and other quinazoline alkaloids have been confirmed in Galega spp.Laakso 1990 Other constituents, including peganine, various flavonoids, saponins, and tannins, are also present in goat's rue.Bisset 1994, Chevallier 1996, Fukunaga 1987, Shevchuk 1967, An in vitro study demonstrated that ethanolic (95%) extracts of G. officinalis inhibited the growth of Enterococcus faecalis and Yersinia enterocolitica. Along with Latin botanical names also please give Sanskrit/Hindi names. The plant has no scent unless bruised, in which case it emits a disagreeable odor, from which the name "goat's rue" may have originated. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. View abstract. Lets throw some light on the myriad health benefits of goats rue: Goats rue has been used in the treatment of diabetes mellitus, since the early 1900s. Because of its ability to inhibit platelet aggregation, there may be an increased risk of bleeding and bruising with administration of goats rue.Toxicology Copyright 2023 by RxList Inc. An Internet Brands company. Bailey, C. J. and Day, C. Metformin: its botanical background. Guanidine, a precursor to metformin is responsible for this weight loss effect. We comply with the HONcode standard for trustworthy health information. Diarrhea and hepatomegaly occurred in a woman taking fennel, fenugreek, and goat's rue as galactogogues. However, limited clinical trials exist to support these uses. Postmortem examinations revealed a striking absence of body fat in mice administered goats rue. This plant has been used for centuries in traditional medicine for various health conditions, and the tea is typically consumed for its potential health benefits. Naturwissenschaften 1967;54(8):205. The native Americans utilized the herb as an aphrodisiac and to help with male impotence. Biochem.J 1923;17(6):836-838. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. A high-calorie diet without exercise causes weight as well as fat gain. View abstract. Avoid use. The parts that grow above the ground are used to make medicine. Keeler, R. F., Johnson, A. E., Stuart, L. D., and Evans, J. O. Toxicosis from and possible adaptation to Galega officinalis in sheep and the relationship to Verbesina encelioides toxicosis. 2002;44(1-2):45-49. (Lemus 1999) The chromium salt content of goats rue may also possess antidiabetic effects. Besides this, the blood level of calcium, albumin, white blood cells and platelet count were reduced in animals who were put on a diet containing goats rue. Pharmazie 1967;22(5):261. These include: They inhibit the processes that induce cancer and thus, help in the treatment and management of cancer. Folia Med.(Plovdiv.) Taking goat's rue along with medications that also slow blood clotting might increase the chances of bruising and bleeding. Pharm Pharmacol Lett 1996;6:86-9. Diabetes Care 2004;27(7):1791-1793. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (Lemus 1999) The chromium salt content of goats rue may also possess antidiabetic effects. (Mooney 2008)Animal and in vitro dataIn studies investigating the effects of goats rue on weight, a reversible, marked weight-reducing effect was demonstrated in mice, regardless of food intake. Use caution if administering goats rue during surgical procedures due to a potential increased risk of bleeding.Pregnancy/Lactation Gonzalez-Andres, F., Redondo, P. A., Pescador, R., and Urbano, B. 2005;35(3):258-260. Atanasov, A. T. Effect of Galega officinalis L. extract on platelet aggregation in rats. View abstract. The plant helps reduce triglycerides, cholesterol, and body weight levels. Information regarding safety and efficacy in pregnancy is lacking. Antibacterial effectsAnimal and in vitro dataAn in vitro study demonstrated that ethanolic (95%) extracts of G. officinalis inhibited the growth of Enterococcus faecalis and Yersinia enterocolitica. 2008;153(8):1669-1677. Sprains. 1. Sneha strongly believes that a healthy diet and lifestyle modifications are the best ways to prevent and treat diseases. 2-28-2008;116(1):21-26. View abstract. Huxtable CR, Dorling RR, Colegate SM. Keep in mind that natural products are not always necessarily safe and dosages can be important. Silymarin in combination with galega enhances milk production in breast-feeding mothers.Interactions (Lee 2012)Dosing Nutr.Metab Cardiovasc.Dis. Genus:Galega officinalisPronunciation: (Guh-LEE-guh uh-fiss-ih-NAL-iss) Family: Leguminosae. Comments & ratings on the side effects, benefits, and effectiveness of goat's rue. Reuter, G., Barthel, A., and Steiniger, J. Pract Diab Int 2004;21(3):115-117. Arch.Pharm 1962;295/67:271-275. View abstract. It has been used to treat digestive problems including indigestion and chronic constipation caused by not enough digestive enzymes as well as bring relief for bee stings and snake bites. (Petricic 1982) In another study investigating the mechanism by which fractions of the plant exert hypoglycemic effects, inhibition of glucose transport across monolayers of human intestinal cells occurred in a dose-dependent manner. Share. Goats rue has the ability to prevent the production of pro-inflammatory compounds, which give rise to inflammation. Postmortem examinations revealed a striking absence of body fat in mice administered goats rue. Goat's rue is also thought to improve the quality of breast milk. It also grows wild in damp fields in Britain.Pundarikakshudu 2001 The plant, which prefers damp, low-lying areas and sandy soil, grows to about 1 m in height. Some people use herbal combinations that include goat's rue as a tonic and for blood purification.. Manganese enhances the hypoglycemic effect of insulin and helps in the breakdown of fat. In a study of preterm infants, silymarin in combination with galega enhanced milk production in breast-feeding mothers.Zecca 2016, Additive blood glucoselowering effects may occur if using goats rue concomitantly with other hypoglycemic medications such as insulin and sulfonylureas.Neef 1996, Because goats rue inhibits platelet aggregation, the risk of bleeding may be increased when given concomitantly with other antiplatelet medications or anticoagulants.Atanasov 1999, Atanasov 2000, Atanasov 2002, Headache, jitteriness, or weakness may occur. Pharm Pharmacol Lett 1996;6:86-9. The dried aerial parts of the plant are harvested during the summer flowering season and used medicinally. Hadden, D. R. Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection. Prolactin is a hormone responsible for the secretion of milk in breastfeeding mothers. View abstract. (Bisset 1994)Clinical dataIn a clinical study, 100 mothers with preterm infants were randomized to receive a galactogogue containing silymarin-phosphatidylserine and galega at a dosage of 5 g/day or placebo from days 3 to 28 postdelivery. The appropriate dose of goat's rue depends on several factors such as the user's age, health, and several other conditions. Keeler, R. F., Baker, D. C., and Panter, K. E. Concentration of galegine in Verbesina encelioides and Galega oficinalis and the toxic and pathologic effects induced by the plants. Goat's rue is used along with conventional treatment for diabetes and as a diuretic. No adverse effects were reported. FERRARI, G. [New method of preparation of galegine from the seeds of Galega officinalis.]. (Pundarikakshudu 2001), Due to its potential diuretic effects, goats rue might be considered for disturbances related to secretion of fluids, such as GI ailments (eg, fermentive dyspepsia, gastrocardiac syndrome, diarrhea). 2008;153(8):1669-1677. View abstract. Toxicity has been observed with other guanidine derivatives. Significantly higher milk production was noted with treatment at 7 days and 30 days compared with placebo (P<0.05). Phenolic substances are health-enhancing compounds, which are present in abundance in goats rue. The parts that grow above the ground are used to make medicine. Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L. Vet.Hum.Toxicol. Rutin, a compound present in this plant acts as an antioxidant and an anti-diabetic agent. Many studies have shown that goat's rue supplements can help people with diabetes lower their blood sugar levels. Arch.Pharm 1962;295/67:271-275. Serratia Marcescens that causes meningitis, septicemia, eye infections, urinary tract infections and respiratory tract infections.
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